Low Osmobility, Low Viscosity, Clinically insignificant effect on haemodynamics and cardiovascular parameters, High Hydrophilicity, Low Protein binding, Low adverse drug reaction, better safety profile.
Lumbar, thoracic, cervical & total columnar myelography, CNS & CT scanning, Angiography, Peripheral venography, Excretion urography, Antegrade and retrograde pyelograph, Contrats enhancement of CT scans, Direct cholangiography, Splenopostgraphy, Hysterosalpingogrophy, Arthrography, Gastrointestinal studies.
Depends on the type and technique of investigation but usually ranges from 5-250 ml.
Previous adverse reaction to lohexol or other iodinated radiological contrast agents, allergy to other drugs, asthma and atopy, poor cardiac function, impaired renal function, myeloma and waldenstrom’s macroglobulinemia, sickle cell disease, suspected cerebral infarct, phaeochromocytoma, pregnancy, a history of epilepsy if use in the subarachnoid space is contemplated.
Special Precautions :
Severe cardiovascular disease, renal impairment, myelomatosis, phaeochromocytoma, sickle cell disease, poor general health, chronic alcoholism, multiple sclerosis, bronchial asthma, diabetes, epilepsy, dehydration, elderly, pregnancy, lactation, children, neonates.
Bronchospasm, angioneurotic ocedema and cardiovascular collapse may occur but these are rare. Acute pulmonary oedema may result from administration of any hyperosmolar agent to patients with poor cardiac function. Contrast agents may induce a variety of cardiac dysrhythmias, in particular, they may reduce the threshold for ventricular fibrillation. After myelography, headache is common and nausea, vomiting and dizziness are most frequent adverse reactions. Good hydration of the patient must be encouraged both before and after exami.